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Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

《医学前沿（英文）》 2020年 第14卷 第5期   页码 642-650 doi: 10.1007/s11684-019-0719-3

摘要： This study aimed to investigate the correlation between serum miR-154-5p and urinary albumin to creatinine ratio (UACR) in patients with type 2 diabetes mellitus (T2DM) and the association with biomarkers of inflammation and fibrosis in diabetic kidney disease (DKD). A total of 390 patients with T2DM were divided into three groups: normal albuminuria (UACR<30 mg/g, =136, NA), microalbuminuria (UACR at 30–300 mg/g, =132, MA), and clinical albuminuria (UACR>300 mg/g, =122, CA). Circulating miR-154-5p, inflammatory (C-reactive protein (CRP); erythrocyte sedimentation rate (ESR); and tumor necrosis factor-α (TNF-α) and fibrotic markers (vascular endothelial growth factor (VEGF); transforming growth factor-β1 (TGF-β1); and fibronectin (FN)), and other biochemical indicators were assessed via real-time PCR, enzyme-linked immunosorbent assay, and chemiluminescence assay in patients with T2DM and 138 control subjects (NC). UACR, miR-154-5p, glycated hemoglobin (HbA1c), serum creatinine (sCr), blood urea nitrogen (BUN), ESR, CRP, VEGF, TNF-α, TGF-β1, and FN were significantly higher and the estimated glomerular filtration rate (eGFR) was significantly lower in NA, MA, and CA groups than in NC subjects ( <0.05). Elevated levels of UACR and miR-154-5p were directly correlated with HbA1c, sCr, BUN, ESR, CRP, VEGF, TNF-α, TGF-β1, and FN and negatively correlated with eGFR ( <0.05). miR-154-5p, HbA1c, sCr, BUN, eGFR, ESR, CRP, VEGF, TNF-α, TGF-β1, and FN were important factors affecting UACR. These findings indicated that elevated serum miR-154-5p is significantly correlated with high UACR in patients with T2DM and may offer a novel reference for the early diagnosis of DKD.

关键词： type 2 diabetes mellitus     diabetic kidney disease     miR-154-5p     urinary albumin to creatinine ratio    

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Small cell carcinoma of the urinary bladder without gross hematuria: a case report

null

《医学前沿（英文）》 2015年 第9卷 第3期   页码 384-387 doi: 10.1007/s11684-015-0405-z

摘要：

Small cell carcinoma of the urinary bladder (SCCB) is a rare and aggressive form of bladder cancer with poor prognosis. Hematuria is the main symptom of this malignancy, and most patients have a history of smoking. The disease incidence of malignant bladder tumors in China is approximately 0.74%. Early and accurate diagnosis of SCCB can ensure timely and appropriate treatment of this malignant disease. Oncologic surgery is the standard treatment; however, it may not be a curative approach. Chemotherapy and/or radiotherapy should be performed following surgical removal. This case report describes a patient with a single neoplasm diagnosed as SCCB that arose because of recurrence of bladder cancer after bladder tumor resection. In contrast to previously reported cases, this patient had no gross hematuria and no history of smoking.

关键词： carcinoma     small cell     urinary bladder neoplasms     diagnosis    

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Expression of renal cubilin and its potential role in tubulointerstitial inflammation induced by albumin

YANG Jurong, HE Yani, SHEN Haiying, DING Hanlu, LI Kailong, WANG Huiming

《医学前沿（英文）》 2008年 第2卷 第1期   页码 25-34 doi: 10.1007/s11684-008-0006-1

摘要： Sustained proteinuria is an independent risk factor leading to kidney fibrosis and end-stage renal failure. Over-reabsorption of filtered proteins, notably albumin, has been proved to trigger interstitial inflammation and fibrosis in proteinuric renal disease. Cubilin, an endocytic receptor expressed on the renal tubular brush border, is responsible for albumin reabsorption in physiologic condition. However, little is known about whether it is required for activation of tubular cells induced by albumin overload. In this work, we investigated the change of cubilin expression and its potential role in albumin-induced up-regulation of chemokines synthesis and . Twenty-six patients with nephrotic syndrome were enrolled in this study. Proximal tubule uptake of albumin, expression of apical membrane cubilin and infiltrating cells in kidney interstitium were determined by immunocytochemistry. , the transcription of cubilin in HK2 cells after exposure to albumin was analyzed by real-time PCR. Endocytosis of albumin in HK2 cells was examined by fluorescent microscope. The influence of inhibition of cubilin on albumin-induced expressions of monocyte chemoattractant protein 1 (MCP-1) and regulated upon activation normal T-cell expressed and secreted (RANTES) was investigated by Western blot. The intensity of luminal cubilin and tubular accumulation of albumin were significantly increased in nephrotic kidneys. The expression of MCP-1 and RANTES was up-regulated, and there were spatial relationships in localization between these chemokines and cubilin as well as intracellular albumin in kidney tissues. Infiltration of CD-3 and ED-1-positive cells was predominant in tubulointerstitial areas displaying signs of increases of cubilin expression and albumin accumulation. , the transcription of cubilin mRNA in HK2 cells was enhanced after 24 h exposure to albumin in a dose-dependent manner. Inhibition of endocytosis of albumin by antisense cubilin nucleotide markedly reduced expression of MCP-1 and RANTES. Cubilin was required for handling a greater amount of protein in nephrotic status and albumin-induced production of MCP-1 and RANTES by renal tubular cells, which further initiated tubulointerstitial inflammation in proteinuric disease.
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Effect of electrokinetic property of charged polyether sulfone membrane on bovine serum albumin fouling

Xiaorong Meng, Shanshan Huo, Lei Wang, Xudong Wang, Yongtao Lv, Weiting Tang, Rui Miao, Danxi Huang

《环境科学与工程前沿（英文）》 2017年 第11卷 第2期 doi: 10.1007/s11783-017-0907-9

摘要： Negatively charged CMPES and positively charged QAPES membranes were fabricated. Charge modification reduced the adhesion forces between PES UF membranes and BSA. QAPES-BSA / was weaker than that of CMPES-BSA at pH 3 and on the contrary at pH 9. Flux decline rate was positively correlated with the adhesion forces of membrane-BSA. Variation of adhesion was consistent with that of potential absolute values. Negatively charged carboxymethylated polyethersulfone (CMPES) and positively charged quaternized polyethersulfone (QAPES) ultrafiltration (UF) membranes were prepared by bulk chemical modification and non-solvent induced phase separation method. The effects of PES membrane interfacial electrokinetic property on the bovine serum albumin (BSA) membrane fouling behavior were studied with the aid of the membrane-modified colloidal atomic force microscopy (AFM) probe. Electrokinetic test results indicated that the streaming potential (D ) of QAPES membrane was not consistent with its expected value, however, within the pH range of 3–10, the potentials of two charged-modified PES membranes were more stable than the unmodified membrane. When pH value was 3, 4.7 or 9, the interaction behavior between charged PES membrane and BSA showed that there was significant linear correlation between the jump distance of membrane-BSA adhesion force ( ) and the potential absolute value. Charged modification significantly reduced the adhesion of PES membrane-BSA, and the adhesion data was good linear correlated with the flux decline rate in BSA filtration process, especially reflected in the CMPES membrane. The above experimental facts proved that the charged membrane interfacial electric double layer structure and its electrokinetic property had strong ties with the protein membrane fouling behavior.

关键词： Charged PES UF membrane     BSA     Electrokinetic characterization     Adhesion force     Jump distance    

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油压极值比与极值比效率

齐茂林

《中国工程科学》 2001年 第3卷 第4期   页码 73-75

摘要：

文章应用基础公式，推导液压系统油压极值比与极值比效率之间的关系式。该式说明，油压极值比越大，极值比效率就越低。提出了油压极值比是可以设计和选择的。

关键词： 油压极值比     极值比效率     液压系统    

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Controlling interstory drift ratio profiles via topology optimization strategies

《结构与土木工程前沿（英文）》 2023年 第17卷 第2期   页码 165-178 doi: 10.1007/s11709-022-0892-3

摘要： An approach to control the profiles of interstory drift ratios along the height of building structures via topology optimization is proposed herein. The theoretical foundation of the proposed approach involves solving a min–max optimization problem to suppress the maximum interstory drift ratio among all stories. Two formulations are suggested: one inherits the bound formulation and the other utilizes a p-norm function to aggregate all individual interstory drift ratios. The proposed methodology can shape the interstory drift ratio profiles into inverted triangular or quadratic patterns because it realizes profile control using a group of shape weight coefficients. The proposed formulations are validated via a series of numerical examples. The disparity between the two formulations is clear. The optimization results show the optimal structural features for controlling the interstory drift ratios under different requirements.

关键词： interstory drift ratio     aggregation function     bound formulation     min–max problem     topology optimization    

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Treatment of infant postrenal acute renal failure following obstruction due to upper urinary calculi

Hui-Xia ZHOU MD, Zhi-Chun FENG MD, Hao MENG MD, Xiao-Guang ZHOU MD, Shuang LI BM, Jun WANG MM, Shi-Xi DAI BM,

《医学前沿（英文）》 2010年 第4卷 第1期   页码 127-130 doi: 10.1007/s11684-010-0009-6

摘要： The surgical emergency treatments and curative effects of postrenal acute renal failure following obstruction due to upper urinary calculi in infants were evaluated. Of the 13 infants with postrenal acute renal failure following obstruction due to upper urinary calculi, 11 received retrograded catheterizations of the ureter with semi-rigid ureteroscopy (F 6.8), and two received open ureterolithotomy. The results showed that only one infant had anuresis and continuous reduction of hemoglobin 5h after the open ureterolithotomy and received exploration via excision and peritoneal dialysis, and the remaining 12 patients well recovered in this group. The renal function of all the patients was restored without postoperative complications. It is concluded that the retrograded catheterization of the ureter with ureteroscopy is a minimally invasive, safe and effective therapy for postrenal acute renal failure following obstruction due to upper urinary calculi in infants. For those infants whose urethras are thin and small, the open ureterolithotomy is a suitable method. But patients with bleeding tendency need to be corrected prior to the open ureterotomy to remove obstructions.

关键词： infant     acute renal failure     postrenal     ureteroscopy    

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Effect of effluent organic matter on ozonation of bezafibrate

Huan HE,Qian SUI,Shuguang LU,Wentao ZHAO,Zhaofu QIU,Gang YU

《环境科学与工程前沿（英文）》 2015年 第9卷 第6期   页码 962-969 doi: 10.1007/s11783-015-0772-3

摘要： The influence of three effluent organic matter (EfOM) model compounds, humic acid (HA), bovine serum albumin (BSA), and sodium alginate (AGS), on the ozonation of bezafibrate (BF), a typical pharmaceutical and personal care product (PPCP), was investigated. The results show that ozonation efficiently removed BF from aqueous solution with removal efficiencies>95% within 8 min for all conditions. The reaction rate of BF decreased with increasing model compounds concentrations and the influence was more pronounced for HA and BSA, while less pronounced for AGS. Although BF concentration was significantly reduced, the degree of mineralization achieved was only approximately 11%. The addition of HA and BSA improved the mineralization of the solution, while the influence of AGS was minor. The acute toxicity of BF solution during ozonation was determined using the Luminescent bacteria test, and the toxicity exhibited an initial increase and a successive reduction. An overall decreased acute toxicity was observed with an increase of HA. The presence of BSA increased the formation rate of toxicity intermediates and resulted in inhibition peak forward.

关键词： ozonation     bezafibrate     acute toxicity     humic acid     bovine serum albumin     sodium alginate    

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A methodology of implementing target mixing ratio for asphalt mixture

Yucheng HUANG, Lun JI, Rui WEN, Ming ZHANG

《结构与土木工程前沿（英文）》 2017年 第11卷 第3期   页码 308-314 doi: 10.1007/s11709-017-0405-y

摘要： In order to implement the objective mix design of hot mix asphalt adequately during the construction process, the significance of objective mixing ratio was elaborated, and the variability of materials and its control method were analyzed. An engineering example is used to illustrate the debugging process of asphalt mixture batching & mixing plant and the dynamic quality management methods. The results show that the set of methods can not only implement the objective mixing ratio of hot mix asphalt adequately, but also control production during the construction process effectively.

关键词： asphalt mixture     target mixing ratio     mix design implementation     batching & mixing plant debugging    

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Diagnostic evaluation of plasma aldosterone concentration to plasma renin activity ratio in primary aldosteronism

ZHANG Huilan, WANG Daowen

《医学前沿（英文）》 2008年 第2卷 第1期   页码 11-14 doi: 10.1007/s11684-008-0003-4

摘要： Using the plasma aldosterone concentration to plasma renin activity ratio (PAC/PRA ratio) as the screening test of choice for primary aldosteronism in hypertensive patients, we studied the clinical characteristics and the diagnostic value of PAC/PRA ratio in primary aldosteronism. The plasma aldosterone concentration (PAC) and plasma renin activity (PRA) levels were measured by radioimmunoassay in 902 hypertensive patients from out-patient clinics or hospitals. One hundred and twenty-six suspected primary aldosteronism patients whose PAC/PRA ratio was > 25 ng/dL/ng/mL/hr had a lamellar computed tomography (CT) scan in the adrenal gland and follow-up visits. The proportion of primary aldosteronism in hypertensive patients was 14% (126/902). There were 54 patients with unilateral or bilateral hyperplasia and 25 patients with adenoma according to the CT scan. 39% (49/126) of the patients with primary aldosteronism had hypokalemia. Twenty-five patients received surgical treatment. The efficacy and cure rates were 100% (25/25) and 48% (12/25), respectively. The effective rate of aldactone and the single-drug cure rate were 89% (48/54) and 24% (13/54), respectively. Primary aldosteronism affects over 10% of hypertensive patients in China. The PAC/PRA ratio can be considered as a routine screening test in hypertensives, especially resistant hypertensive patients and a high PAC/PRA ratio is an invaluable index in primary aldosteronism diagnosis.
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Enhancing the efficiency of nitrogen removing bacterial population to a wide range of C:N ratio (1.5:

《环境科学与工程前沿（英文）》 2022年 第16卷 第8期 doi: 10.1007/s11783-022-1522-y

摘要：

• Simultaneous C & N removal in Methammox occurs at wide C:N ratio.

关键词： Methanogens     Biological Nitrogen Removal (BNR)     Simultaneous     Methammox     C:N ratio    

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Dynamics analysis of bladder-urethra system based on CFD

Qinghua JIN, Xiaojun ZHANG, Xiaoyang LI, Jianliu WANG,

《机械工程前沿（英文）》 2010年 第5卷 第3期   页码 336-340 doi: 10.1007/s11465-010-0027-8

摘要： A mathematical model for a bladder-urethra system can provide basic analysis for the disabled urethra closure of stress urinary incontinence (SUI) patients in a clinic. Based on computational fluid dynamics (CFD), we developed a three-dimensional urodynamic bladder-urethra system, which includes bladder, bladder neck, prostate, and urethra. The realistic recirculation process of the urinary bladder during the physiologic voiding process in conjunction with a flow simulation through the female urinary bladder and urethra is presented. The computational results show that a dead-water zone and the zone of secondary flow occur, independent of the shape of the prostatic urethra. For the pathological prostata, the extreme constriction of the prostatic urethra results in an additional wide-stretched dead-water zone. The simulation results does not only improve urinary incontinence surgery for clinicians, but can also provide a basis for theoretical analysis.

关键词： bladder-urethra system     stress urinary incontinence (SUI)     computational fluid dynamics (CFD)     urodynamics    

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Experimental study of structural damage identification based on modal parameters and decay ratio of acceleration

Zhigen WU, Guohua LIU, Zihua ZHANG

《结构与土木工程前沿（英文）》 2011年 第5卷 第1期   页码 112-120 doi: 10.1007/s11709-010-0069-3

摘要： A novel damage assessment method based on the decay ratio of acceleration signals (DRAS) was proposed. Two experimental tests were used to show the efficiency. Three beams were gradually damaged, and then the changes of dynamic parameters were monitored from initial to failure state. In addition, a new method was compared with the linear modal-based damage assessment using wavelet transform (WT). The results clearly show that DRAS increases in linear elasticity state and microcrack propagation state, while DRAS decreases in macrocrack propagation state. Preliminary analysis was developed considering the beat phenomenon in the nonlinear state to explain the turn point of DRAS. With better sensibility of damage than modal parameters, probably DRAS is a promising damage indicator in damage assessment.

关键词： damage assessment     decay ratio of acceleration signals (DRAS)     wavelet transform (WT)     modal analysis     reinforced concrete beam     beat phenomenon    

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The influence of the NCO/OH ratio and the 1,6-hexanediol/dimethylol propionic acid molar ratio on the

Jiao Feng, Qiuhao Lu, Weimin Tan, Kequan Chen, Pingkai Ouyang

《化学科学与工程前沿（英文）》 2019年 第13卷 第1期   页码 80-89 doi: 10.1007/s11705-018-1763-2

摘要：

1,5-Pentamethylene diisocyanate, a novel aliphatic diisocyanate formed from bio-based 1,5-pentamethylenediamine, has been used as a hard segmented material to synthesize polyurethane. In this study, several waterborne polyurethane (WPU) dispersions have been successfully prepared by a prepolymer process from 1,5-pentamethylene diisocyanate poly(polyether) with different NCO/OH ratios and 1,6-hexanediol (HDO)/dimethylol propionic acid (DMPA) molar ratios. The Fourier transform infrared (FTIR) spectra, thermogravimetric analysis, differential scanning calorimetry, X-ray diffraction, and a mechanical tensile test were used to investigate the structures, thermal stability, phase separation, crystallinity, mechanical properties, and adhesive performance of the WPU dispersions. The FTIR results indicate that the degree of hydrogen bonding and the numbers of urea groups increase as the NCO/OH ratio and HDO/DMPA molar ratio increase. Furthermore, the phase separation increases and the thermal stability decreases as the NCO/OH ratio increases or the HDO/DMPA molar ratio decreases. Finally, WPU3.0-2.4 (NCO/OH=3, HDO/DMPA=2.4) exhibits a maximum tensile strength and shear strength, pointing to its possible use as an adhesive. These results could provide a very valuable reference for industrial applications of WPU.

关键词： 1     5-pentamethylene diisocyanate     polyurethane     water based    

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Long term performance of recycled concrete beams with different water–cement ratio and recycled aggregate

Jingwei YING; Feiming SU; Shuangren CHEN

《结构与土木工程前沿（英文）》 2022年 第16卷 第3期   页码 302-315 doi: 10.1007/s11709-022-0803-7

摘要： The purpose of this study is to reveal the service performance of recycled aggregate concrete (RAC) components for different values of water−cement ratio and replacement rate of recycled coarse aggregate (RCA). Generally, the concrete strength decreases with the increase of the replacement rate of RCA, in order to meet the strength requirements when changing the replacement rate of RCA, it is necessary to change the water−cement ratio at the same time. Therefore, the axial compressive strengths of prism with 25 mix proportions, the short-term mechanical properties and long-term deformation properties of reinforced concrete beams were tested respectively by changing water−cement ratio and RCA replacement rate. The bearing capacity and the strain nephogram of samples under different loads were obtained using the Digital Image Correlation (DIC) method, and a self-made gravity loading experimental device was used for long-term deformation investigation. Results showed that the damage pattern of RAC was the same as that of natural aggregate concrete (NAC), but the brittleness was more pronounced. The brittleness of concrete before failure can be reduced more effectively by adjusting the replacement rate of RCA than by adjusting the water−cement ratio. The water−cement ratio has an evident influence on the axial compressive strength and early creep of concrete, while the replacement rate of RCA has a remarkable effect on the long-term deformation of the concrete beams.

关键词： recycled concrete     beam     the replacement rate of recycled coarse aggregate     water–cement ratio     digital image correlation    

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标题 作者 时间 类型 操作

Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetes

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

期刊论文

Small cell carcinoma of the urinary bladder without gross hematuria: a case report

null

期刊论文

Expression of renal cubilin and its potential role in tubulointerstitial inflammation induced by albumin

YANG Jurong, HE Yani, SHEN Haiying, DING Hanlu, LI Kailong, WANG Huiming

期刊论文

Effect of electrokinetic property of charged polyether sulfone membrane on bovine serum albumin fouling

Xiaorong Meng, Shanshan Huo, Lei Wang, Xudong Wang, Yongtao Lv, Weiting Tang, Rui Miao, Danxi Huang

期刊论文

油压极值比与极值比效率

齐茂林

期刊论文

Controlling interstory drift ratio profiles via topology optimization strategies

期刊论文

Treatment of infant postrenal acute renal failure following obstruction due to upper urinary calculi

Hui-Xia ZHOU MD, Zhi-Chun FENG MD, Hao MENG MD, Xiao-Guang ZHOU MD, Shuang LI BM, Jun WANG MM, Shi-Xi DAI BM,

期刊论文

Effect of effluent organic matter on ozonation of bezafibrate

Huan HE,Qian SUI,Shuguang LU,Wentao ZHAO,Zhaofu QIU,Gang YU

期刊论文

A methodology of implementing target mixing ratio for asphalt mixture

Yucheng HUANG, Lun JI, Rui WEN, Ming ZHANG

期刊论文

Diagnostic evaluation of plasma aldosterone concentration to plasma renin activity ratio in primary aldosteronism

ZHANG Huilan, WANG Daowen

期刊论文

Enhancing the efficiency of nitrogen removing bacterial population to a wide range of C:N ratio (1.5:

期刊论文

Dynamics analysis of bladder-urethra system based on CFD

Qinghua JIN, Xiaojun ZHANG, Xiaoyang LI, Jianliu WANG,

期刊论文

Experimental study of structural damage identification based on modal parameters and decay ratio of acceleration

Zhigen WU, Guohua LIU, Zihua ZHANG

期刊论文

The influence of the NCO/OH ratio and the 1,6-hexanediol/dimethylol propionic acid molar ratio on the

Jiao Feng, Qiuhao Lu, Weimin Tan, Kequan Chen, Pingkai Ouyang

期刊论文

Long term performance of recycled concrete beams with different water–cement ratio and recycled aggregate

Jingwei YING; Feiming SU; Shuangren CHEN

期刊论文